March 10, 2014 – EnWave Corporation
EnWave Corporation (TSX-V:ENW | FSE:E4U) (“EnWave”, or the “Company”) announced today that it has signed a Testing Agreement (the “Agreement”) with a Tier 1 pharmaceutical company (the “Tier 1”) that is in the top five globally for Research and Development spending. The Agreement allows the Tier 1 to exclusively test EnWave’s Radiant Energy Vacuum (“REV™”) technology for the dehydration of monoclonal antibodies (“mAbs”). The testing period is expected to begin in late March 2014.
Prior to signing this Agreement, EnWave received positive results in 2011 from a 12 month study comparing the Company’s REV® dehydration technology against the standard industrial drying method, freeze drying, in the dehydration of pure samples of a FITC-conjugated and unconjugated animal-derived mAbs. The results showed that the drying methods were equivalent in terms of the structural changes incurred by the antibodies both immediately post-dehydration, and over the course of the 12 month shelf-life period, but that the samples dried using REV® were dehydrated in considerably less time than required for freeze drying. This was a significant test result as mAbs are much more sensitive and therefore prone to degradation during dehydration.
mAbs are produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies. Beyond basic research, in recent years, therapeutic mAbs have become an increasingly important component of pharmacotherapy and have made a significant impact on the drug discovery and development process.
Although antibodies are not considered live organisms, dehydration can cause them to become inactive, and therefore ineffective for use in pharmaceutical and other products, by changing or “denaturing” their outer protein structure.
“We have proven that REV™ technology can efficiently dehydrate monoclonal antibodies while preserving their efficacy,” stated Dr. Tim Durance, Chairman & Co-CEO of EnWave Corporation. “This Agreement will provide the opportunity to exhibit the value proposition to this leading Tier 1 pharmaceutical partner.”
EnWave Corporation is a Vancouver-based industrial technology company developing commercial applications for its proprietary Radiant Energy Vacuum (REV™) dehydration technology. EnWave aims to sign royalty-bearing commercial licenses with leading food and pharmaceutical companies for the use of its revolutionary technology. Thus far the Company has signed commercial licenses with Bonduelle, a global leader in the production of vegetables, for the processing of dehydrofrozen vegetables; Hormel Foods Corporation, a major processed meat manufacturer, for the production of healthy dried meat products; Milne Fruit Product, EnWave’s first major licensee, for the production of several dehydrated fruit and vegetable products in the whole, fragmented and powdered form; a leading North American enzyme company, to dehydrate a series of food-related enzymes for their Tier 1 clients; and Napa Mountain Spice Company, to dry high-quality California bay leaves. In addition to these licenses, EnWave has formed a Limited Liability Partnership with Lucid Capital Management to develop, manufacture, market and sell all-natural cheese snack products in the United States under the Moon Cheese® brand.
Also, EnWave has entered into a wide range of research and collaboration agreements with an expanding list of multinational companies. EnWave is introducing REV™ as a new dehydration standard in the food and biological material sectors: potentially faster and cheaper than freeze drying, with better end product quality than air drying or spray drying.
EnWave currently has six REV™ platforms: commercial-scale nutraREV® and MIVAP® are used in the food industry to dry fruits, vegetables, meat, herbs and seafood quickly and at low-cost, while maintaining high levels of nutrition, taste, texture and colour. The Company is also developing powderREV™ for bulk dehydration of food cultures, probiotics and fine biochemicals such as enzymes; quantaREV™ for continuous, high-volume low-temperature drying of pastes, gels, liquids, or particulates; and bioREV™ and freezeREV™ as new methods to stabilize and dehydrate biopharmaceuticals such as vaccines and antibodies. More information about EnWave is available at www.enwave.net.
Dr. Tim Durance
Chairman and Co-CEO
For further information:
Mr. Brent Charleton, Vice President, Corporate Affairs at (778) 378-9616
Mr. John McNicol, President & Co-CEO, EnWave Corporation at (604) 601-8524
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