Biochemical Characterization Team Lead – Senior/Principal Scientist
Biochemical Characterization Team Lead - Senior/Principal Scientist
Permanent, Full Time
HOW MIGHT YOU DEFY IMAGINATION?
If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Join us.
Amgen is a global biotechnology company that discovers and develops breakthrough therapies to treat serious human illnesses. Our mission is to serve patients around the world and our medicines have made a dramatic difference in the lives of millions. Amgen British Columbia is a centre of excellence dedicated to the discovery of fully human therapeutic monoclonal antibodies. Our high-energy research team has a history of success in contributing to Amgen’s exciting portfolio of biologic medicines.
What you will do
Let’s do this. Let’s change the world.
We are looking for a Senior / Principal Scientist with an enthusiasm for the biochemical and bioanalytical characterization of antibodies to join our research team. You will primarily be responsible to oversee a small research team that is responsible for high throughput affinity ranking of large antibody panels against many diverse antigens. The goal of these characterization efforts is the selection of a lead panel of potential drug candidates at the initial stages of the development of a human therapeutic.
This is a permanent role that offer potential for advancement and career development. Successful candidates must be able to work onsite at our Burnaby, BC office.
What we expect of you
The successful candidate will have extensive knowledge of different affinity determination methodologies and the experience to understand the appropriate application of these methods to different target classes. The ideal candidate will enjoy laboratory work and provide leadership and mentorship for our research site in their field of expertise. They will also possess an enthusiasm for tackling difficult research challenges and a positive approach to working in a team-based research environment.
Ph.D. and postdoc in Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related discipline with 5+ years of related experience
A track record of scientific accomplishments in the biophysical characterization of antibody interactions with soluble and cell-expressed antigens.
Broad knowledge of different affinity determination methodologies and their application including Kinetic Exclusion Analysis (KinExA), Bio-layer Interferometry (ForteBio Octet) and surface plasmon resonance (Carterra, Biacore).
Deep understanding of bioanalytical techniques and analytical methods for Ab molecules to identify molecule liabilities (Ie. Tm/Tagg, viscosity)
Demonstrated history of strong hands-on capabilities, problem solving, and independent experimental design and execution
Familiarity with antibody discovery processes would be an asset
Strong written and verbal communication and interpersonal skills
Track record of management experience with the ability to inspire and grow a high-performing team, chart and set team goals into action, and forge productive cross-site collaborations with partner functions
What you can expect of us
As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.
Vast opportunities to learn and move up and across our global organization
Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits
Amgen endeavors to make its recruitment process accessible to any and all users. Reasonable accommodations will be provided, upon request, to applicants with disabilities in order to facilitate equal opportunity throughout the recruitment and selection process. Please contact TalentAcquisitionInquiries@amgen.com to make a request and ensure you include the requisition number.